Stk11^tm1.1Gne

---

Species

Mus musculus

Symbol

Stk11^tm1.1Gne

Category

allele

Allele of gene

Stk11

Transgenic Constructs

None

Synonyms

• Lkb1^M129G
• Lkb1^MG

Description

Exon 3 was replaced with a modified exon 3 in which nucleotide substitutions replaces a methionine with glycine at position 129 (M129G). This mutation is expected to disrupt the gatekeeper residue in the ATP-binding pocket possibly rendering the protein susceptible to small molecular analogues of the general kinase inhibitor PP1. Cre-mediated recombination removed the floxed neo cassette inserted downstream of exon 2. Activity assay confirmed the sensitivity to 1NMPP1 inhibition.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations