Allele/Variant

Tg(LCR-HBA1,LCR-HBB*)1Tow

Species
Mus musculus
Symbol
Tg(LCR-HBA1,LCR-HBB*)1Tow
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Tg(LCR-HBA1,-HBB*)1Tow
Description
Two transgenes were designed to each be controlled independently by five upstream sites (HS I-V) of the human beta-globin locus control regions (LCR). The HS I-V betaS transgene expresses a glutamic acid to valine mutation of the human hemoglobin beta chain complex (HBB) that has been linked to sickle cell disease. The HS I-V alpha transgene expresses a human alpha1 globin (HBA1) gene. Line 1 was generated.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations