Allele/Variant

Tg(Prnp*P101L)174Sbp

Species
Mus musculus
Symbol
Tg(Prnp*P101L)174Sbp
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Tg(GSSPrP)174
  • Tg(MoPrP-P101L)174
Description
This transgene consists of the murine Prnp with a proline to leucine substitution at codon 101 (equivalent to codon 102 in human PRNP). This construct was generated using a chimeric murine cosmid constructed by exchanging the BamHI-SalI fragment containing the open reading frame from a recombinant NZW genomic clone for the corresponding fragment in an ILn/J mouse cosmid. An approximate 100-nucleotide region flanking codon 101 leucine was modified to yield DNA sequence homology to hamster Prnp while retaining amino acid homology to mouse Prnp. Analysis indicated that this line carries approximately 64 haploid transgene copies inserted into a single autosomal site. Three lines were created: 174, 180, and 196.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
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