Allele/Variant

Siglecetm1Arte

Species
Mus musculus
Symbol
Siglecetm1Arte
Category
allele
Allele of gene
Siglece
Transgenic Constructs
None
Synonyms
  • siglec-E R126D
Description
Exon 1 was replaced with one in which nucleotide substitutions result in the amino acid substitution of aspartic acid for arginine at position 126 (R126D). This mutation destroys the sialic acid binding site. An FRT-flanked neomyocin resistance cassette with a 5'loxP site was inserted downstream of exon 3. An additional loxP site was inserted downstream of exon 6.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations