Allele/Variant

Tg(MECP2*G273X/GFP)AHzo

Species
Mus musculus
Symbol
Tg(MECP2*G273X/GFP)AHzo
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • G273XTg
  • MeCP2-G273X
Description
A human PAC (PAC671D9) containing only the MECP2 locus and regulatory elements was modified to replace amino acids 270-486 with MECP2 sequence encoding amino acids 270-272, a 6 amino acid poly-serine linker and a C-terminal GFP tag. Two lines were generated. Expression of the transgene faithfully reproduces the distribution, abundance, and subnuclear localization of MECP2 in the brain.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
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