Allele/Variant

Tg(Thy1-APPSweLon)41Ema

Species
Mus musculus
Symbol
Tg(Thy1-APPSweLon)41Ema
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • APP41
  • mThy1-hAPP751
Description
The murine Thy1 promoter drives expression of the hAPP751 cDNA containing the Swedish (K670N/M671L) and the London (V717I) mutations. Immunohistochemistry confirmed high expression of human APP in the neocortex and hippocampus and moderate expression in the thalamus, basal ganglia, and cerebellum. Three lines were made, 16, 11, and 41. Line 41 is the highest expressing line.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
    Disease
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