Version: 8.0.0
Date: Tue Jan 28 2025
Raxtm1.1(rTA,tetO-cre)Lan
MGI:5494255
Allele of Rax
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Raxtm1.1(rTA,tetO-cre)Lan

Species
Mus musculus
Symbol
Raxtm1.1(rTA,tetO-cre)Lan
Category
allele
Allele of gene
Rax
Transgenic Constructs
Synonyms
  • Rx-tTA:TetOp-Cre
Description
A cassette encoding an IRES-tTA (tetracycline transactivator) and tetO-cre was inserted into the 3' UTR of the Rax (Rx) gene, 104 bp from the stop codon. A neo resistance marker was included in the cassette. The construct was electroporated into ES cells for homologous recombination. Correctly targeted germline mutants were crossed to flpe-expressing transgenic mice to remove the neo marker. Further breeding to wild-type mice removed the flpe transgene. Removal of doxycycline from the animals' diets permits Rax-dependent cre expression.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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