Allele/Variant

Tg(Col1a1-FGF2*,-Sapphire)305Mmh

Species
Mus musculus
Symbol
Tg(Col1a1-FGF2*,-Sapphire)305Mmh
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • 18-kDa(305)TgFGF2
  • Col3.6- LMW-IRES-GFPsaph
Description
A transgene designed to contain the human low-molecular weight exported 18-kDa isoform of FGF2, an internal ribosome entry site (IRES), and a blue shifted variant of GFP known as Sapphire under the control of a 3.6 kb fragment of the Col1a1 5' regulatory region (Col3.6). The construct also harbors a neomycin selection cassette. Founder line 305 was established. Western blot analysis demonstrates high levels of expression of 18-kDa FGF2 in femurs and calvariae, low levels of expression in liver, and no expression in other tissues.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations