Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Eomestm1.1(cre/ERT2)Sjar
- Species
- Mus musculus
- Symbol
- Eomestm1.1(cre/ERT2)Sjar
- Category
- allele
- Allele of gene
- Eomes
- Transgenic Constructs
- Synonyms
- EomesCreER
- Description
- A cre/ERT2-polyA cassette and loxP-flanked neomycin selection cassette were inserted into the Eomes locus at the translational start site in exon 1 by homologous recombination. This resulted in deletion of about 500 bp of the coding region of exon 1 (creating a null allele). The neo selection cassette was deleted in the final knockin allele. In situ hybridization demonstrated that embryonic expression of cre/ERT2 recapitulated the spatiotemporal expression pattern of endogenous Eomes.
- Additional Information
- Literature
Transgenic Constructs
This allele contains 1 transgenic construct- Symbol
- Expressed Components
- None
- Knock-down Targets
- None
- Regulatory Regions