Allele/Variant

Spi1tm4.1Dgt

Species
Mus musculus
Symbol
Spi1tm4.1Dgt
Category
allele
Allele of gene
Spi1
Transgenic Constructs
None
Synonyms
  • PU.1ki
Description
A targeting vector introduced the floxed nucleotide substitution of GGAA to TCGC in the 14 kb upstream regulatory element (URE) at the PU.1 site. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted upstream of the modified region. Real-time PCR confirmed reduced transcript expression. This allele is hypomorphic.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations