Allele/Variant

Igf2rtm1.1(IGF2R)Arte

Species
Mus musculus
Symbol
Igf2rtm1.1(IGF2R)Arte
Category
allele
Allele of gene
Igf2r
Transgenic Constructs
None
Synonyms
  • Igf2rHU
Description
A targeting vector inserted an FRT-flanked human cDNA (exons 3 through 48) into intron 2. Cre-mediated recombination removed the floxed puromycin resistance cassette inserted downstream of the human cDNA. This allele is humanized. Western blot analysis confirmed reduced protein expression in the lower limb and heart when the allele is inherited maternally. Paternal inheritance of the allele does not exhibit altered protein expression.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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