Rc3h1^tm1.2Cgv

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Species

Mus musculus

Symbol

Rc3h1^tm1.2Cgv

Category

allele

Allele of gene

Rc3h1

Transgenic Constructs

None

Synonyms

• Rc3h1^rin
• ringless

Description

LoxP sites were inserted flanking exon 2 and an FRT flanked neo cassette was inserted in intron 2. Properly targeted mice were then crossed to mice expressing flp recombinase to remove the selection cassette. Finally, mice were crossed to cre expressing mice to excise exon 2 which contains the RING domain. A smaller, in frame transcript was produced reflecting the absence of the RING domain.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations