Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Prnp-ATXN3*148Q)NLS.28Olri
MGI:5516462Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Prnp-ATXN3*148Q)NLS.28Olri

Species
Mus musculus
Symbol
Tg(Prnp-ATXN3*148Q)NLS.28Olri
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
None
Description
The mouse prion promoter (containing 1140 bp of the prion protein gene upstream of exon 1, the complete exon 1, intron 1, and the first 52 bp of exon 2) drives the expression of the full-length human ATAXIN-3 (ATAXIN-3c isoform) containing 148 CAG repeats. For nuclear targeting of ATAXIN-3, three repeats of the nuclear localization signal from the SV40 T antigen were cloned at the C terminus of ATAXIN-3. Three lines were established: NLS.28, NLS.10, and NLS.37.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
    References
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