Allele/Variant

Trp53tm1Thst

Species
Mus musculus
Symbol
Trp53tm1Thst
Category
allele
Allele of gene
Trp53
Transgenic Constructs
None
Synonyms
  • p53LSL-RR
  • Trp53LSL-E177R
Description
Exon 5 was replaced with a modified one in which nucleotide substitutions (GA-to-CG) result in the amino acid substitution of glutamic acid with arginine at position 177 (p.E177R), mimicking a mutation found in some human tumors. A loxP site flanked puromycin resistance gene cassette was inserted into intron 1. Authors state that this is a null allele.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations