Allele/Variant

Tg(Hoxa5-cre)447BLjea

Species
Mus musculus
Symbol
Tg(Hoxa5-cre)447BLjea
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Tg(14.5kb Hoxa5-cre)Ljea
Description
A 5 kb genomic fragment of Hoxa5 (containing the temporal (T) control region, the brachial spinal cord (BSC) enhancer, proximal Hoxa5 promoter, both exons and the intron of Hoxa5) drives cre epxression in this transgene. An IRES-EGFPcre cassette was inserted into exon 1 of Hoxa5 downstream of the translation initiation codon. A 2.1 kb fragment containing the mesodermal (MES) enhancer and an additional 7.4-kb of downstream sequences including an enhancer driving lung and gut (L/G) expression were added at the 3' end of the construct to produce the 14.5 Hoxa5/Cre transgene. Eight founder lines were obtained and line 447B was established. This line has 6 copies of the transgene.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
  • Hoxa5
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
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