Allele/Variant

Prkcitm2.1(Prkcz)Ltg

Species
Mus musculus
Symbol
Prkcitm2.1(Prkcz)Ltg
Category
allele
Allele of gene
Prkci
Transgenic Constructs
None
Synonyms
  • PKCiota/lambda Res
Description
The cDNA encoding Prkcz followed by a floxed neomycin resistance cassette was inserted into the coding sequence of exon 2. Cre-mediated recombination removed the neomycin resistance cassette. This allele expresses a fusion protein consisting of the first 28 amino acids of the endogenous sequence and the remaining 564 amino acids of the knocked-in sequence. Western blot analysis confirmed the absence of endogenous protein expression and expression of the knock-in sequence in E9.5 embryos.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
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