Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Pcp2-ATXN3*69Q)bHirai
MGI:5523235Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Pcp2-ATXN3*69Q)bHirai

Species
Mus musculus
Symbol
Tg(Pcp2-ATXN3*69Q)bHirai
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Tg(b)
Description
The cDNA encoding a N-terminal-truncated form (lacking 286 amino-acid residues) of human ATAXIN-3 with 69 glutamine repeats is driven by a Purkinje-cell specific L7 promoter (Pcp2). The ATG start codon in exon 2 of Pcp2 was mutated to inhibit the expression of exons 1-3. In addition an N-terminal hemagglutinin epitope was added. Three lines were generated, a, b, and c.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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