Allele/Variant

Tg(Prnp-MAPT*P301L)#Ruvi

Species

Mus musculus

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

Tg-Tau

Description

The murine Prnp promoter drives the expression of the smallest 4-repeat human isoform of MAPT (Tau) with the frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) P301S mutation. Southern blot analysis indicates one integration site and incorporation of approximately 60-70 copies of the transgene. 8 founders were established, however the pound symbol (#) is used when line is not specified and/or lines are pooled.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

MAPT (Hsa)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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