Allele/Variant

Tg(ACTB-KRAS*G12V,-luc)#Lche

Species

Mus musculus

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

RASLO

Description

A transgene consisting of a 1.8 kb chicken beta-actin promoter, a floxed STOP codon, a mutated KRAS^VAL12, a polyoma virus internal ribosomal re-entry site, and a fusion molecule consisting of chicken ovalbumin, an S-tag and a luciferase molecule. Expression of the constitutively active oncogenic KRAS^V12 is dependent on Cre-mediated deletion of the STOP codon. The pound symbol (#) is used because a line number was not specified.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

Kras

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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