Allele/Variant

Tg(Aire-cre/ERT2*)1Mand

Species

Mus musculus

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

Aire-Cre

Description

A targeting construct was used for recombineering to insert an ERT2-cre-ERT2 sequence (cre fused to two mutated human estrogen receptor ligand-binding domains) into a BAC containing the Aire locus. The inducible cre cassette replaced exon 2 of Aire. The resulting linearized BAC was injected into fertilized FVB oocytes. Founder and line number information is not available.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

None

Knock-down Targets

None

Regulatory Regions

Aire

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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