Allele/Variant

Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo

Species
Mus musculus
Symbol
Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo
Category
allele
Allele of gene
Gt(ROSA)26Sor
Transgenic Constructs
Synonyms
  • R26-LRRK2
Description
The targeting vector contains a SV40 splice acceptor, a loxP-flanked STOP cassette (PGK-neo and triple SV40 transcriptional termination sequence), a full-length human leucine-rich repeat kinase 2 cDNA bearing a familial Parkinson's disease-linked missense mutation R1441C, and a bovine polyadenylation signal.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal dopaminergic neuron morphologyMGI
no abnormal phenotype detectedMGI
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Disease Associations

No data available