Version: 8.0.0
Date: Tue Jan 28 2025
Tnfaip3tm4.1Ama
MGI:5528685
Allele of Tnfaip3
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tnfaip3tm4.1Ama

Species
Mus musculus
Symbol
Tnfaip3tm4.1Ama
Category
allele
Allele of gene
Tnfaip3
Transgenic Constructs
None
Synonyms
  • Tnfaip3ZF4
Description
Exon 7 was replaced with one in which nucleotide substitutions result in the amino acid susbtitutions of alanine for cysteine at positions 609 and 612 (C609A, C612A). This mutation disrupts the zinc finger 4-based E3 ligase and ubiquitin binding. Cre-mediated recombnation removed the floxed neomycin resistance cassette inserted downstream of the modified exon 7.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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