Allele/Variant

Tg(Sirt1)ASrn

Species

Mus musculus

Symbol

Tg(Sirt1)ASrn

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

Sirt1-tg
SIRT1^super

Description

Bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a 174 kb BAC (#RP23-119G23) containing the entire mouse Sirt1 gene and the adjacent Dnajc12 gene. Overexpression of Dnajc12 is not expected to affect Sirt1 molecular pathways. The one founder mouse created exhibits a 2-4 fold overexpression of SIRT1 protein in liver, kidney, thymus, spleen, colon and jejunum/ileum.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

Sirt1 (Mmu)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype	Annotation details	Source	References
No records match query. Try removing filters.

Showing 0 - 0 of 0 rows

per page

Disease Associations

Association	Disease Qualifier	Disease	Annotation details	Evidence	Source	References
No records match query. Try removing filters.

Showing 0 - 0 of 0 rows

per page