Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Ank3tm2.2Bnt
- Species
- Mus musculus
- Symbol
- Ank3tm2.2Bnt
- Category
- allele
- Allele of gene
- Ank3
- Transgenic Constructs
- None
- Synonyms
- None
- Description
- A loxP site was inserted upstream of exon 22. An FRT-flanked neomycin resistance cassette with a 3' loxp site was inserted downstream of exon 23. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exons 22 and 23. Western blot analysis confirmed the loss of the 190-, 270- and 480-kDa isoforms in the brain and the loss of the 190 kDa isoform but retention of the 150, 120 and 90 kDa isoforms in the kidney.
- Additional Information
- Literature