Version: 7.5.0
Date: Fri Dec 13 2024
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H2-Ab1
b-tm1Wug
MGI:5543894
Allele of
H2-Ab1
Mus musculus
Summary
Transgenic Constructs
Genomic Variant Information
Variant Molecular Consequences
Phenotypes
Disease Associations
Allele/Variant
H2-Ab1
b-tm1Wug
Species
Mus musculus
Symbol
H2-Ab1
b-tm1Wug
Category
allele
Allele of gene
H2-Ab1
Transgenic Constructs
None
Synonyms
H2-Ab1
tm1Wug
IAbeta
b
stop
f
Description
A floxed neomycin resistance/STOP cassette was inserted into intron 1. Flow cytometry confirmed the absence of protein expression in the peripheral blood, spleen and bone marrow.
Additional Information
Literature
Transgenic Constructs
No data available
Genomic Variant Information
No data available
Variant Molecular Consequences
No data available
Phenotypes
Phenotype
Clear
Apply
Annotation details
Source
Clear
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References
Clear
Apply
abnormal B cell physiology
View
Name
Type
Experimental condition
Modifier
References
H2-Ab1
b-tm1Wug
/H2-Ab1
b-tm1Wug
Cd19
tm1(cre)Cgn
/Cd19
+
[background:] involves: 129S2/SvPas * C57BL/6
genotype
PMID:23772037
H2-Ab1
b-tm1Wug
/H2-Ab1
b-tm1Wug
[background:] involves: C57BL/6
genotype
PMID:23772037
MGI
PMID:23772037
abnormal dendritic cell physiology
View
Name
Type
Experimental condition
Modifier
References
H2-Ab1
b-tm1Wug
/H2-Ab1
b-tm1Wug
[background:] involves: C57BL/6
genotype
PMID:23772037
H2-Ab1
b-tm1Wug
/H2-Ab1
b-tm1Wug
Cd19
tm1(cre)Cgn
/Cd19
+
[background:] involves: 129S2/SvPas * C57BL/6
genotype
PMID:23772037
MGI
PMID:23772037
absent CD4-positive, alpha-beta T cells
View
Name
Type
Experimental condition
Modifier
References
H2-Ab1
b-tm1Wug
/H2-Ab1
b-tm1Wug
[background:] involves: C57BL/6
genotype
PMID:23772037
MGI
PMID:23772037
decreased susceptibility to experimental autoimmune encephalomyelitis
View
Name
Type
Experimental condition
Modifier
References
H2-Ab1
b-tm1Wug
/H2-Ab1
b-tm1Wug
[background:] involves: C57BL/6
genotype
PMID:23772037
H2-Ab1
b-tm1Wug
/H2-Ab1
b-tm1Wug
Cd19
tm1(cre)Cgn
/Cd19
+
[background:] involves: 129S2/SvPas * C57BL/6
genotype
PMID:23772037
MGI
PMID:23772037
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