Allele/Variant

Topbp1tm1.1Zqw

Species
Mus musculus
Symbol
Topbp1tm1.1Zqw
Category
allele
Allele of gene
Topbp1
Transgenic Constructs
None
Synonyms
  • TopBP1ki
  • TopBP1W1147R
Description
Tryptophan 1147 in exon 20, the core indispensable aromatic residue in the ATR activating domain was changed to arginine by introducing a T3439C mutation. In addition an FRT flanked neo cassette was inserted in intron 19. Flp mediated recombination removed the neo cassette leaving a single FRT site in intron 19. Immunoblot analysis confirmed similar levels of protein expressing in heterozygous and wild-type MEFs.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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