Ret^tm1.1Vlcg

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Species

Mus musculus

Symbol

Ret^tm1.1Vlcg

Category

allele

Allele of gene

Ret

Transgenic Constructs

None

Synonyms

None

Description

A conditional by inversion (COIN) intron consisting of a lox66_SA-Egpf-polyA_lox71 was inserted in the antisense orientation into exon 2 via homologous recombination, splitting exon 2 into 2 new exons (121 and 143 bp in length). The two lox sites are in reverse complementation orientation, thus cre-mediated recombination will irreversibly invert the inserted sequence. In addition, an FRT flanked drug selection cassette (hygromycin- or neomycin-delta-thymidine kinase cassette was inserted after the COIN intron. Flp-mediated recombination removed the drug selection cassette.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations