Allele/Variant

Tg(Msx2-rtTA)888Lma

Species
Mus musculus
Symbol
Tg(Msx2-rtTA)888Lma
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
None
Description
This transgene consists of a 187 kb BAC clone, RP24-512K19, containing the endogenous Msx2 locus and flanking sequences (134 kb upstream and 47 kb downstream of Msx2; accession number AC154808) and a modified rtTA gene that replaced part of the first exon right after the start codon, followed by a FRT-flanked neomycin cassette and polyA sequences and was made using a two-step recombineering strategy. Two founding lines were established, 885 and 888. Western blot analysis failed to detect any truncated or fusion Msx2 protein. This BAC clone contains six additional predicted genes, which may be overexpressed.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
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