Allele/Variant

Afmidtm1b(EUCOMM)Wtsi

Species
Mus musculus
Symbol
Afmidtm1b(EUCOMM)Wtsi
Category
allele
Allele of gene
Afmid
Transgenic Constructs
None
Synonyms
None
Description
Cre-mediated excision of the parental Afmidtm1a(EUCOMM)Wtsi allele resulted in the removal of the promoter-driven neomycin selection cassette and the critical exon 2 leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. qRT-PCR on liver and kidney confirmed absence of RNA in homozygotes. RNA expression of the immediately adjacent Tk1 gene is reduced by 52% in the kidney and 94% in liver of homozygotes.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations