Allele/Variant

Tg(PDGFB-APPInd)F17Plhn

Species
Mus musculus
Symbol
Tg(PDGFB-APPInd)F17Plhn
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Tg-betaCTF99
Description
This transgene consists of the platelet-derived growth factor beta promoter, the human APP signal sequence, the amyloid beta containing carboxy-terminal 99 amino acids of APP with the Indiana V717F mutation and the SV40 polyadenylation sequence. The Kozak sequence (GACC) was introduced in front of the ATG codon of the signal sequence to increase translation efficiency. 16 Founder lines were established. This is the highest expressing line.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations