Version: 8.0.0
Date: Tue Jan 28 2025
Tg(tetO-MAPT*K280,-luc)#Eman
MGI:5554185Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(tetO-MAPT*K280,-luc)#Eman

Species
Mus musculus
Symbol
Tg(tetO-MAPT*K280,-luc)#Eman
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • proaggregation
  • TauRD/deltaK280
Description
The tetracycline response element with a bidirectional CMV promoter drives inducible expression of the four-repeat domain on human MAPT (TauRD; 244-372 aa) carrying the frontotemporal dementia and parkinsonism linked to chromosome 17 Lys280 deletion (deltaK280), and a luciferase gene. The Lys280 deletion accelerates aggregation of MAPT (Tau).
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
    References
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