Version: 8.0.0
Date: Tue Jan 28 2025
Tg(tetO-MAPT*K280*I277P*I308P,-luc)#Eman
MGI:5554188Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(tetO-MAPT*K280*I277P*I308P,-luc)#Eman

Species
Mus musculus
Symbol
Tg(tetO-MAPT*K280*I277P*I308P,-luc)#Eman
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • antiaggregation
  • TauRD/deltaK280/I277P/I308P
Description
The tetracycline response element with a bidirectional CMV promoter drives inducible expression of the four-repeat domain on human MAPT (TauRD; 244-372 aa) carrying the frontotemporal dementia and parkinsonism linked to chromosome 17 Lys280 deletion (deltaK280) and two proline mutations in the hexapeptide motifs, I277P and I308P, and a luciferase gene. The Lys280 deletion accelerates aggregation while the proline mutations inhibit MAPT (Tau) aggregation.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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