Allele/Variant

Tg(Thy1-APPSweAut)A7Tiwa

Species
Mus musculus
Symbol
Tg(Thy1-APPSweAut)A7Tiwa
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • A7 APP Tg
  • Tg(Thy1-APP*K670N*M671L*T714I)A7Tiwa
Description
This transgene expresses the human APP695 harboring the Swedish K670N and M671L (Swe) and the Austrian T714I (Aut) familial Alzheimer disease mutations in neurons under the control of the Thy1.2 promoter. Immunoblotting shows that expression of transgenic human APP proteins is about 1.4 fold that of endogenous murine App.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
    Disease
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