Allele/Variant

Tg(INS-HBEGF*L148S*P149T)70Rin

Species
Mus musculus
Symbol
Tg(INS-HBEGF*L148S*P149T)70Rin
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • INS-TRECK-Tg
  • Tg(INS-TRECK/DTR)1Rin
Description
This transgene consists of the 1.9 kb human insulin promoter region, rabbit beta-globin intron, human diphtheria toxin receptor (HBEGF) with L148S/P149T mutations, and the polyadenylation signals of rabbit beta-globin and SV40. It was injected into the pronucleus of Prkdcscid eggs. Transgene expression is seen in pancreatic beta cells and administration of diphtheria toxin results in HBEGF expressing cells.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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