Hprt1^{tm367a(Ple251-icre/ERT2)Ems}

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Species

Mus musculus

Symbol

Hprt1^{tm367a(Ple251-icre/ERT2)Ems}

Category

allele

Allele of gene

Hprt1

Transgenic Constructs

Synonyms

• C8ORF46-creERT2
• mEMS5937

Show All 3

Description

The transgene was designed with an HS4 insulator region, the 2453 bp Ple251 minipromoter (derived from a portion of the endogenous promoter and three upstream putative regulatory elements from the human uncharacterized protein C8ORF46), a chimeric intron cassette, the iCre/ERT2 fusion gene (with F3-frt sites flanking the ERT2 sequences), the mut6-WPRE element, an SV40 early polyA signal, an additional HS4 insulator region, a human HPRT complementary sequence (containing exon 1, intron 1, exon 2, and part of intron 2), a mouse 3' Hprt homology arm, an I-Sce linearization cut site, and a mouse 5' Hprt homology arm.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations