Allele/Variant

Ahrtm1.2Arte

Species
Mus musculus
Symbol
Ahrtm1.2Arte
Category
allele
Allele of gene
Ahr
Transgenic Constructs
None
Synonyms
None
Description
Exon 3 was replaced with the floxed human cDNA spanning exons 3 through 11. Flp-mediated recombination removed the selection marker. Cre-mediated recombination removed the human cDNA. Western blot analysis confirmed the absence of protein expression in the testis, epididymis, caudal sperm and liver.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal cauda epididymis morphology
MGI
abnormal male germ cell apoptosis
MGI
abnormal seminiferous tubule epithelium morphology
MGI
abnormal sperm head morphology
MGI
abnormal spermiation
MGI
coiled sperm flagellum
MGI
decreased epididymis weight
MGI
decreased fertilization frequency
MGI
decreased testis weight
MGI
multinucleated giant male germ cells
MGI
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Disease Associations

No data available