Allele/Variant

Ryr2tm2.1Wex

Species
Mus musculus
Symbol
Ryr2tm2.1Wex
Category
allele
Allele of gene
Ryr2
Transgenic Constructs
None
Synonyms
  • RyR2-S2814D
Description
Exon 56 was replaced with one containing nucleotide substitutions that result in the amino acid substitution of aspartic acid for serine at position 2814 (S2814D). This mutation produces a constitutively active protein. The modified exon was followed by a floxed neo cassette that was removed by subsequent cre-mediated recombination.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations