Allele/Variant

Tg(Stat3*)9199Alau

Species
Mus musculus
Symbol
Tg(Stat3*)9199Alau
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • mut-Stat3
  • Stat3-deltaV463
Description
This transgene consists of a bacterial artificial chromosome (RP24-236G5 BAC) containing mouse Stat3 that was modified to delete valine 463 from the binding domain. The deletion consists of a 1,163 bp DNA fragment starting with the last codon of Stat3 exon 15 and ending at the 5' end of exon 16. This mutation affects Stat3 DNA binding activity in a dominant negative way. Line 9199 (L1) contains 2 transgene copies.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations