Allele/Variant

Scn8aem1Mm

Species
Mus musculus
Symbol
Scn8aem1Mm
Category
allele
Allele of gene
Scn8a
Transgenic Constructs
None
Synonyms
  • Scn8aN1768D
  • Scn8atm1768DMm
Description
TALEN technology was used to generate an A to G point mutation in exon 26 that results in the amino acid substitution of aspartic acid for asparagine at position 1768 (N1768D). Seven more synonymous changes within the TALEN binding sites were introduced to minimize redigestion of the targeted allele. 62 founders were identified with 13 distinct insertion/deletions in 24 mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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