Allele/Variant

Tg(Prnp-MAPT*)2652Gds

Species
Mus musculus
Symbol
Tg(Prnp-MAPT*)2652Gds
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Tau4RTg2652
  • Tg(pThy1.2-MAPT*)2652Gsd
Description
The 1N4R brain isoform of human MAPT (microtubule associated protein, tau) is expressed under the control of the mouse neuron-specific prion protein (PrP) promoter. Hemizygous mice exhibit approximate 12-fold overexpression of human tau relative to endogenous mouse tau and show consistent transmission of approximately 143+/-20 copies of the transgene.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
    Disease
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