Shcbp1^{tm1c(EUCOMM)Wtsi}

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Species

Mus musculus

Symbol

Shcbp1^{tm1c(EUCOMM)Wtsi}

Category

allele

Allele of gene

Shcbp1

Transgenic Constructs

None

Synonyms

• Shcbp1^FL

Description

The L1L2_Bact_P cassette was inserted at position 4798418 of Chromosome 8 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 4800268. The critical exon(s) are thus flanked by loxP sites. The lacZ and neomycin segments were excised with germline Actin-Flp recombinase, leaving exons 4 and 6 flanked by loxP sites. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations