Tg(Neurod1-cre/ERT2)M1Fcal

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Species

Mus musculus

Symbol

Tg(Neurod1-cre/ERT2)M1Fcal

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

• Neurod1-CreER^T2

Description

Bacterial artificial chromosome (BAC) library (Source BioScience) was used to obtain a 160 kb BAC (BMQ-305H2) containing the entire mouse Neurod1 gene. This BAC was modified to replace the coding region with a creERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand-binding domain) followed by a frt-flanked neomycin (neo) selection cassette. Four lines were generated: L (low expression), M1 (intermediate expression), M2, H (high expression). This is a representative record for all lines. Transgene expression patterns are consistent with endogenous gene expression.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations