Version: 8.0.0
Date: Tue Jan 28 2025
Gja1tm3.1Clo
MGI:5584311
Allele of Gja1
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Gja1tm3.1Clo

Species
Mus musculus
Symbol
Gja1tm3.1Clo
Category
allele
Allele of gene
Gja1
Transgenic Constructs
None
Synonyms
  • Cx43-MK4A
  • Gja1tm1.1Beis
Description
A cassette containing the non-coding exon 1, and a neo/PGK cassette flanked by loxP sites followed by exon 2 that contains the whole Gja1 coding sequence including the mutations S255A, S262A, S279A, and S282A, was inserted into the endogenous locus. The neomycin selection cassette was removed by breeding with Tg(CMV-cre)1Cgn mice. These serine to alanine mutations prevent Gja1 phosphorylation by mitogen-activated protein kinase.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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