Allele/Variant

Gt(ROSA)26Sortm2(Sirt1)Ktm

Species
Mus musculus
Symbol
Gt(ROSA)26Sortm2(Sirt1)Ktm
Category
allele
Allele of gene
Gt(ROSA)26Sor
Transgenic Constructs
None
Synonyms
  • Rosa26Sirt1-H355Y
Description
A targeting construct introduced into the locus a splice acceptor, floxed neomycin resistance/STOP cassette and cDNA with nucleotide substitution(s) result(s) in the amino acid substitution of tyrosine for histidine at position 355 (H355Y). This mutation is predicted to generate an enzyme dead protein.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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