The transgenic construct contains Aimp1 sequence, derived from Methylcholanthrene A (Meth A)-transformed mouse fibrosarcoma cells and encoding mature secreted EMAPII protein, fused to an IFN-beta signal peptide sequence, under the control of the tetO, tetracycline-responsive regulatory element (seven copies of the 42-bp tet operator sequence placed between two minimal CMV enhancer-less promoters).