Lyn^M1Btlr

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Species

Mus musculus

Symbol

Lyn^M1Btlr

Category

allele

Allele of gene

Lyn

Transgenic Constructs

None

Synonyms

• Lemon

Description

The Lemon mutation is an A to G transition at base pair 3,746,768 (Build 38) on Chromosome 4, which is base pair 68,648 of the genomic region containing Lyn (GenBank NC_000070). The mutation, in the seventh of the gene's 13 exons, corresponds to nucleotide (nt) 794 of the mRNA sequence (NM_001111096) encoding the long isoform of the LYN protein (Lynp56) and to nt 731 of the transcript (NM_010747) encoding the short protein isoform (Lynp53). Alternative splicing of exon 2 produces mRNAs encoding the two protein isoforms, which differ at their amino (N) termini; Lynp56 is 21 amino acids longer than Lynp53. The Lemon mutation results in a histidine (H) to arginine (R) substitution at position 182 (H182R) in the Lynp56 (ENSMUSP00000038838) isoform and at position 162 (H162R) in the Lynp53 (ENSMUSP00000100075) isoform.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations