Version: 8.0.0
Date: Tue Jan 28 2025
Plcl1tm2.1Matk
MGI:5607952
Allele of Plcl1
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Plcl1tm2.1Matk

Species
Mus musculus
Symbol
Plcl1tm2.1Matk
Category
allele
Allele of gene
Plcl1
Transgenic Constructs
None
Synonyms
  • PlceRAm
Description
Three point mutations (R2130L, K2151E, and Y2154L) were introduced into exons 29 and 30 and an FRT flanked selection cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. The point mutations disrupt the Ras binding domain in the RA2 domain of the protein. Quantitative RT-PCR indicates that mRNA expression in homozygous mice is similar to wild-type controls.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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