Version: 8.0.0
Date: Tue Jan 28 2025
Slc6a3tm4.1(tTA)Xz
MGI:5619093
Allele of Slc6a3
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Slc6a3tm4.1(tTA)Xz

Species
Mus musculus
Symbol
Slc6a3tm4.1(tTA)Xz
Category
allele
Allele of gene
Slc6a3
Transgenic Constructs
None
Synonyms
  • DAT-PF-tTA
Description
The following were inserted, in order, between the promoter and coding sequences of the endogenous gene: tTA-pA-STOP-"PF" [TetO-tTA] cassette-pA-loxP-Neo-loxP. The PF (positive feedback) amplification cassette enhances tTA expression following the removal of the STOP. Cre-mediated recombination removed the downstream floxed neo cassette. Transgene expression is eight-fold higher than endogenous alpha-synuclein expression in dopaminergic neurons.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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