Allele/Variant

Tg(SOD1*)D-14Dbo

Species
Mus musculus
Symbol
Tg(SOD1*)D-14Dbo
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • Cu-V103Z
Description
This transgene contains a variant of human SOD1 that encodes a termination at codon position 103 (V103Z) with mutations at histidines at positions 46, 48, and 63 to R, Q, and G, respectively, to eliminate copper binding. In addition introns between exons 3, 4, and 5 of SOD1 were removed, creating a fragment with just two introns (one between exon 1 and 2 and one between exon 2 and 3) and exons 3, 4, and 5 fused to make one new exon. Two lines, E-17 and D-14, were established.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations