Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Tg(Mbp-SNCA)29Ema
- Species
- Mus musculus
- Symbol
- Tg(Mbp-SNCA)29Ema
- Category
- allele
- Allele of gene
- None
- Transgenic Constructs
- Synonyms
- MBP halpha-syn tg
- Description
- The murine Mbp promoter drives the expression of human alpha-synuclein cDNA (nucleotides 53-475). Line 29 is the highest expressor, followed by lines 1, 2, and 31. Highest mRNA expression is seen in the corpus callosum, followed by white matter tracts in the brainstem, spinal cord, basal ganglia, and cerebellum and lowest levels in the hippocampus, neocortex, and cortical layers in the cerebellum. Immunohistochemical analysis indicates protein expression in glial but not neuroal cells of the neocortex, basal ganglia, corpus callosum and cerebellum. Four lines were generated; 1, 2, 29, and 31.
- Additional Information
- Literature
Transgenic Constructs
This allele contains 1 transgenic construct- Symbol
- Expressed Components
- Knock-down Targets
- None
- Regulatory Regions
- None